0873
STUDY OF SERUM PROLACTIN AND
NEUROPSYCHOLOGICAL FUNCTION IN TOURETTE SYNDROME Zhang FH 1, Wei SZ2 1 Xinhua Hospital,
Shanghai the Second Medical University Shanghai, China 2 Affiliated Hospital, Qingdao Medical
College, Qingdao, China Objective: to explore the
pathological mechanism of dopamine and neuropsychological changes in
Tourette syndrome. Methods: Three groups were identified: untreated children with Tourette
Syndrome (TS) (n=79), treated children with TS (n=69) and normal control
group (n=15). The serum prolactin (PRL) levels of all subjects were
investigated by Radioimmunity Analysis. 58 children of the untreated group
and the control group were tested by Wechsler Intelligence Scale for
Children-Chinese Revised. All children with TS were assesed with Chinese
Preschool Children Temperament Scale and Chinese School Children
Temperament Scale. Results: 1. The untreated group presented with significantly decreased
PRL level as compared with twe other groups. 2. The full intelligence
quotient (IQ), verbal IQ and performance IQ in TS group showed no
significant difference as compared with control group .The digit span
coding and block design subtest scores in TS group were significantly lower
than those in control group. 3. The distribution of temperament type of TS
group was significantly different from that of norm group. Conclusions: 1. The hyperactivity of dopamine in the central nervous system
may exist in children with TS. Serum prolactin level may be used as a
useful marker in reflecting DA activity and directing the diagnosis and
treatment of TS. 2. There are some changes in the cognitive function of
children with TS. 3. The temperament trait of TS is distinct. It shows the
genetic substrate of TS.