文本框: THE RELATIONSHIP OF HLA DRB1 AND DQB1 GENES AND TSH RECEPTOR BLOCKING ANTIBODY AND THYROID STIMULATING IMMUNOGLOBULIN IN AUTOIMMUNE THYROID DISEASE
Zhang Qin, Li Chengrong, Wang Muti*
Children’s Hospital of Shenzhen, China 
*Department of Pediatrics, Tongji Hospital, Tongji Medical University, Wuhan, China

Objective: We investigated whether the relationship of HLA DRB1, DQB1 and TSH receptor blocking antibody and thyroid stimulating immuno-globulin in auto-immune thyroid disease.
Methods: We analyzed the HLA DRB1, DQB1 genes by polymerase chain reaction with sequence specific primers (PCR, SSP) and TSH receptor blocking antibody and thyroid stimulating immunoglobulin using ELASA in children with 46 Hashimoto’s thyroiditis, 20 with Graves disease and 193 heathy control.
Results: The gene frequency of HLA DRB1*0901 was significantly increased in 29 Hashimoto’s thyroiditis patients that were positive for TSH receptor blocking antibody compared to 193 controls (63% vs. 16%; P<0.01). No specific other DRB1 or DQB1 genes were increased in either TSH receptor blocking antibody and thyroid stimulating immuno-globulin with Hashimoto’s thyroiditis and Graves disease.
Conclusion: We conclude that TSH receptor blocking antibody positive Hashimoto’s thyroiditis is associated with HLA DRB1*0901. It is possible that HLA DRB1*0901 may be involved in the production of TSH receptor blocking antibody in Chinese children.

Key word: Thyroid disease, autoimmune, HLA DRB1, DQB1
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