文本框: ENHANCING EFFECT OF EXOGENOUS GANGLIOSIDES ON LEARNING AND MEMORY IN HYPOXIC-ISCHEMIC BRAIN DAMAGE RATS CAO Y 1, SHAO X-M, MEI Z-T 2. 1 Children’s Hospital, Fudan University Medical Center, Shanghai, China 2 Shanghai Institute of Physiology, Academia Sinica, Shanghai, China Objective: The present work is aimed at investigating the effect of exogenous Gangliosides (GAs) on learning and memory in hypoxic-ischemic (HI) brain damage rats. Methods: Seven-day-old male SD rats underwent right common carotid artery ligation, followed by hypoxia (FiO2=0.08). Rats were injected i.p. immediately after HI every 12 hours for 4 doses with 50mg/kg GAs or saline, followed by a 2 weeks consecutive daily injections at dose of 30mg/kg/day Gas or saline. The behavioral test starded when the animals were 1month old. Discriminative learning ability and memory retention were tested in the tri-equal-arms maze and the alternative behavior was observed to assess the short-term working memory of rats. The degree of neuronal damage was assessed after behavioral test. Results: Two weeks consecutive daily injection of GAs have facilitatory effects on learning ability and memory retention of HI rats (P<0.01) with no effects on short-term working memory (P>0.05). There is no significant difference with regard to brain damage between intervention group and control group (P>0.05). Conclusion: These results show that gangliosides can enhance the learning ability and memory retention in HI rats. 0890