文本框: THE CLINICAL SIGNIFICANCE OF MDR1 EXPRESSION IN CHILDREN ACUTE LEUKEMIA PATIENT Zhang J-B, Lin C-Y, Zhang L-P The First Medical College of Harbin Medical University, China Objective: To discuss the clinical value of expression of MDR1 in children acute leukemia patient. Methods: Expression of MDR1 was measured in 48 samples of 28 CAL patients.20 of them were also observed continuously. Results: The positive rate of MDR1 expression was different in different medical treatment stage in CAL. The rate of MDR1 expression was 25% in initial treating patients. Complete remission rate (33%) was lower in MDR1 positive patients than that (92% p<0.01) in MDR1 negative patients. The positive rate of MDR1 expression in drug-resistant patients (80%) was higher than that (16% p<0.01) in none drug-resistant patients. The positive rate of MDR1 expression in reoccurring patients (75%) was also higher than that (16% p<0.05) in continuous relaxation patient and none of normal controls. Conclusion: The expression of MDR1 can predict the treatment outcome and the prognosis of leukemia patients. The detection of MDR1 can also offer an objective factor in choosing medical treating plan. 0896