文本框: INFECTION-ASSOCIATED HEMOPHAGOCYTIC SYNDROME IN NEWBORN INFANTS: 2 CASES REPORT Jiang Y First Hospital of Beijing University, Beijing, China Objective: Infection-associated hemophagocytic syndrome (IAHS) is a rare disease, especially in newborn infants. Two newborn infants with IAHS who died rapidly after hospitalization were reported. This report was aimed to draw greater attention to this syndrome. Methods: The clinical symptoms, laboratory findings and the therapeutic response of two cases were described. Results: Both cases were female, 13 days and 21 days of age, respectively on admission. They presented with a high fever of unknown origin, weight Loss and reappeared jaundice. Physical examination revealed moist rales at both sides of lungs, abdominal distension and hepatosplenomegaly. The laboratory findings included rapidly progressive anemia and thrombocytopenia, liver function and coagulation abnormalities, leukocytopenia (case 1) or (case 2). EBV-IgM was positive (case 2). Hemophagocytes phagocytizing erythrocytes or platelets were found in the bone marrow of case 1 and in the peripheral blood of case 2. They were treated with antibiotics, antivirus agents, blood or platelet transfusion, immunoglobulin. Eight days after admission, case 1 died of perforation of digestive tract and case 2 died of DIC. Conclusion: IAHS of two infants reported might be associated with EB virus infection or bacterial infection. The early age onset and a fulminate downhill course are the feature of IAHS. The diagnosis should be made on the identification of hemophagocytes from the peripherral blood, bone marrow, lymph nodes, spleen or liver. Differentiation should be made with septicemia. 0897