MOLECULAR EPIDEMIOLOGY OF ADENOVIRUS
PNEUMONIA OF CHANG CHUN STATE IN CHILDREN
Bao J, Sun
LW, Wang JL
Changchun Children’s Hospital, Jilin, China
Objective: To search for the molecular
epidemiology of Adenovirus pneumonia.
Methods: The randomly amplified
polymorphism DNA (RAPD) technology was used to analysis Adenovirus genotype
of 113 ADV stains isolated from the pneumonia infants in Changchun
children’s hospital during
1992-2000 .
Results: The Adenovirus Pneumonia is
gradually reducing in children. The main epidemic ADV genotype was ADV 7b
during 1992-1994 and was ADV3I during 1995-2000. ADV7b
is the most toxic genotype. It has caused severe pneumonia. ADV3 is relatively steady,
and ADV7 is unsteady.
Conclusions: This study shows that the toxicity
is different in different Adenovirus genotype. Analysis of Adenovirus
genotype could study the epidemiology and prognosis of illness in molecular
level. These has the important significance of the study of the gene
vaccine of Adenovirus.
Key words: Adenovirus, Genotype, Infant,
Pneumonia