文本框: PULMONARY FUNCTION IN INFANTS WITH RESPIRATORY SYNCYTIAL VIRUS BRONCHIOLITIS
Rao XC, Liu XC
Beijing Children’s Hospital, Beijing, China

Objective: This study attempted to assess the pulmonary function in infants with respiratory syncytial virus (RSV) bronchiolitis.
Methods: The study was performed in 31 infants with RSV bronchiolitis at admission. In 17 infants, measurements were repeated 1 week and 2 week later. Meanwhile pulmonary function was measured in 74 healthy infants. Tidal breathing flow-volume (TBFV) loops were recorded when infants were breathing quietly. Passive flow-volume technique was used to obtain static respiratory system compliance (Crs) and resistance (Rrs). Functional residual capacity (FRC) was measured by open-circuit nitrogen washout method.
Results: The TBFV loop displayed a concave expiratory curve, Crs were significantly decreased, while Rrs and FRC were increased in infants with RSV bronchiolitis at admission as compared with healthy infants. 1 week later, The TBFV loop showed mild decelerating expiratory limb, Crs were significantly increased, while Rrs and FRC were decreased. Rrs and FRC had attained a normal level, whereas Crs was still lower. 2 week later, each index had recovered normal.
Conclusion: RSV bronchiolitis could damage pulmonary function severely, but did not lead to permanent changes.

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