EFFECT OF IRON DEFICIENCY ANEMIA ON LEARNING AND MEMORY ABILITY AND BRAIN TRACE ELEMENTS IN RATS

Hu R-M, Wei M-W, Sun R-P, Zhang Y.

Department of Pediatrics, Qilu Hospital of Shandong University

 

Objective: To investigate the effect of iron deficiency anemia (IDA) on learning and memory ability and its biochemical basis in rats.

Methods: The iron deficiency anemia animal model was made by feeding the rats a low iron content diet (11.9mg/kg). The learning and memory ability was tested by means of MG-2 model maze. The contents of 7 kinds of trace element in brain were determined by DCP-AES technique.

Results: The rats of experimental group needed more training to reach the learning criterion. The brain iron (Fe) and zine (Zn) contents of experimental group were markedly lower than those of control group. The manganese (Mn) and cadmium (Cd) contents of experimental group were markedly higher than those of control group.

Conclusions: It is suggested that IDA rats had learning and memeory defects that may attribute to abnormal metabolism of trace elements in brain.

 

 
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