CARBAMAZEPINE MONITORING
AND EFFECT OF CEFAZOLIN ON ITS SERUM CONCENTRATION IN CHILDREN WITH
EPILEPSY
Li BM, Sun RP, Wang JW
Qilu Hospital, Shandong University, Jinan, Shandong, China
Objective: To investigate the
factors affecting carbamazepine (CBZ) serum concentration and the effect of
cefazolin on CBZ serum concentration in children with epilepsy.
Methods: The minimum steady-state
concentrations of CBZ of 68 specimens of 49 children with epilepsy were
measured using high-performance liquid chromatography (HPLC).
Results: 1. The minimum steady-state
concentrations of CBZ increased with dose，but no statistical difference was found among the groups of
the children administrated different doses (P＞0.05). It was seen that CBZ
concentrations increased with weight and age of children. However, sex and
the time after administrating CBZ didn’t affect the CBZ serum
concentrations significantly. 2. The serum concentrations of CBZ before and
after coadministrating cefazolin were quantitatively very different
(P=0.0001). We also found that there were much higher concentrations of CBZ
in children with cefazolin comedication than those with monoadministrating
CBZ (P=0.001).
Conclusions: 1. The factors affecting concentration of CBZ were
mainly body weight，age and dosage. There was no significant correlation between the
concentration of CBZ and sex or the time after administrating CBZ. Therefore, CBZ doses that would be
suitable for paediatric patients of different ages or weights are proposed.
And a small CBZ dose at beginning is the best selection to administrate
children with epilepsy. 2. There is a apparent drug interaction between CBZ
and cefazolin. If possible, cefazolin should not be used in the patients
taking CBZ.