文本框: BOLUS INTRAVENOUS INFUSION OF AMINOACIDS INDUCE GALLBLADDER CONTRACTION IN NEONATES ON TOTAL PARENTERAL NUTRITION GAO HM, FAN XM Beijing Children’s Hospital, Beijing, China Objective: Bolus intravenous infusion of amino acids (AA) induce gallbladder contraction in adult patients receiving total parenteral nutrition (TPN). The aim of this study was to test the hypothesis that bolus intravenous infusion of AA combined with cycled infusion of TPN solution, which may mimic the period of starvation in adult, produces gallbladder contraction in neonates receiving TPN. Methods: Twenty-one neonates on TPN were divided into two groups randomly, one received continuous TPN (TPNC group, 9 cases), another received bolus intravenous infusion of AA and a cycled infusion of TPN solution (TPNB group, 12 cases). In TPNB group, A bolus intravenous infusion of AA at the dose of 420 mg/kg for one hour was given every day just before receiving TPN solution. The gallbladder volume was measured by ultrasonography by a single investigator on the 3rd and 7th day after beginning of TPN. Measurements were made before starting the bolus infusion of AA and every 15 minutes for 1 hour in TPNB group, and at an un-electively time in TPNC group. Results: The mean volume of gallbladder in TPNC was 945 mm3 in 3rd day and 998 mm3 in 7th day. The volume of gallbladder before bolus infusion of AA in TPNB on 3rd and 7th day was respectively 892mm3 and 924mm3. The gallbladder begin to contract at 15 minute and the smallest volume gained at 30-45 minute after the bolus infusion which on 3rd and 7th day were respectively 610 mm3 and 717 mm3. Conclusions: Bolus intravenous infusion of AA combined with cycled infusion of TPN solution can induce gallbladder contraction in neonates on TPN, and its effects on TPN associated cholestasis are need to further evaluation. 0920