STUDY ON THE VIRAL
ROLE IN THE PATHOGENESIS OF CHILDHOOD APLASTIC ANEMIA
Qian X-H1, Zheng Y-J1, Zhang G-C1, Jiao X-Y2
1 Xijing
Hospital, Fourth Military Medical University, Xi,an, China
2 Institute
of neuroscience, Fourth Military Medical University, China
Objective: To
investigate the role of virus infections in the occurrence of childhood
aplastic anemia (AA).
Methods: Human
parvovirus B19 (HPV B19)-DNA, Epstein-Barr virus (EBV)-DNA, cytomegalovirus
(CMV)-DNA and five serum markers of hepatitis B virus (HBV) were detected
in 38 children with AA.
Results: Positive HPV
B19-DNA was observed on 9 cases (23.7%) in the AA group and none in the
control group (P=0.00807).
Positive EBV-DNA and HBV-antigens were detected on 1 case and 2 cases,
respectively. The total positive rate of these three viruses was 31.6%
(12/38). No significant statistically difference between acute AA and
chronic AA was observed on all 9 cases with positive HPV B19-DNA (P=0.673).
Conclusions: (1) The pathegenesis of 1/3 AA cases were probably correlated
to viruses infection, specially HPV B19 infection. (2) The pathegenesis of
acute AA and chronic AA were all correlated to HPV B19. (3) HBV remains the
important reason responsible for hepatitis-associated AA in China. It is
possible that EBV may be one of causes in childhood acquired AA.