URINARY EXCRETION OF ALBUMIN IN CHILDREN AND ADOLESCENTS WITH TYPE 1 DIABETES IN SHANGHAI

Shen S-X, Luo F-H, Zhi D-J

Children¡¯s Hospital, Fudan University, Shanghai, China

 

Objective: To investigate the urinary albumin excretion (UAE) in children and adolescents with type 1 diabetes in Shanghai, and to study the relationship of UAE to metabolic control.

Methods: Sixty-five children and adolescents (age:13.41¡À3.12 years) with type 1 diabetes were enrolled in the study. 24 hours urines were collected. Urine albumin was measured by radioimmunoassay.

Results: The duration of diabetes varied between 0.7 to 11.6 years (5.11¡À2.46 years). HbA1c was 9.75% ¡À2.10%. The median UAE was 7.70 ug/min with 95% percentile between 0.58 ug/min to 32.36 ug/min. In patients with duration less than 5 years, the median UAE was 5.63 ug/min (95% percentile: 0.58~81.67 ug/min), the median UAE was 10.03 ug/min (95% percentile: 1.22~29.97 ug/min) in patients with duration more than 5 years, there is a weak statistical significance (p=0.058) between the two groups of patients. Three cases (4.62%) were diagnosed with microalbuminuria. Logistic regression shows that the daily insulin dosage (regression coefficient:-0.10, p=0.039) has negative correlation, HbA1c (regression coefficient:0.67, p=0.059) has positive correlation with UAE.

Conclusion: Even though diabetic nephropathy is uncommon in children and adolescents with type I diabetes, it can occur at different duration of diabetes. Poor insulin regiments and metabolic control have negative effect on diabetic nephropathy.

 

 
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