文本框: LEFT VENTRICULAR FUNCTION OF OBESE CHILDREN BEFORE AND AFTER EXERCISE INTERVENTION Ho TF1, Chan KY2, Lin FP3, Stensel D3 1 National University of Singapore, Singapore 2 Gleneagles Medical Centre, Singapore 3 Nanyang Technological University, Singapore Objective: The aim of this study was to determine left ventricular function in obese children before and after exercise intervention. Methods: Twenty-seven obese boys and 28 non-obese boys (controls) were studied. Obese boys underwent a 12-month exercise intervention consisting of daily aerobic exercises of 20 minutes each, 5 days/week. Their anthropometric measurements [relative weight (RW), BMI] and left ventricular dimensions (LV mass, LV mass index, LVESD, LVEDD, LVPW) were determined before and after intervention. The latter dimensions were measured during echocardiography. Results: Obese boys (before intervention) had higher RW (p<0.0001), BMI (p<0.0001), LV mass and LV mass index compared to controls. After intervention, those who became more obese (n=16) had significant increase in mean RW (144.6±9.1% vs 139.1±9.5%, p<0.0001), BMI (30.1±1.9 kg/m2 vs 28.7±2.0 kg/m2, p<0.0001), LV mass (280.5±74.0 gm vs 251.3±51.5 gm, p=0.014) and LV mass index (160.8±40.8 gm/m vs 147.3±27.4 gm/m, p=0.037) compared to the values before intervention. Those who became less obese (n=6) showed marginal increase in LV mass and LV mass index. Conclusion: Obese boys had bigger LV mass and LV mass index compared to non-obese boys. Following exercise intervention, an increase in obesity may cause further rise in LV dimensions. 0935