Pan K-L1, Fu R1, Niiu X-Q1, Chen W2, Zhang J3, Liu Y-F3

1 Department of Pediatrics, Xijing Hospital, Fourth Military Medical University, Xian, China

2 Department of Nephrology, Xijing Hospital, China

3 Department of Pathology, Preclinical Medicine School, China


Objective: To probe the relations of mesangial proliferative glomerulonephritis (MsPGN) in children and the accompanied infectious vasculitis with nephrotic syndrome. 

Method: Comparative analysis of the pathological and clinical data of 59 children suffered from MsPGN were carried out to determine the degree of the disease, the presence of immunoglubulin deposit and the occurrence of vasculitis. 

Results: 1) 36.36% of the primary MsPGN cases were induced by infections of various types, the respiratory track infection being the most common inducer. 2) The degree of seriousness of the clinically diagnosed MsPGN varied. Mild MsPGN mostly complicated with primary glomerulus, while moderate and severe cases complicated with secondary glomerulus (P<0.05). 3) Inflammation of renal interstitial small vessels was also noticed, but there were significant differences among the 7 groups (P<0.05), the group of hematuresis having more cases of inflammation. 4) The positive rate of immunohistochemisty examination totaled 54.2%, mosly IgG positive. 

Conclusion: MsPGN proved to be the most common nephrotic troubles among children pathologically. IgG deposit appeared mainly in the mesangial area which was complicated with infectious vasculitis. Interstitial small vessels were slightly or moderately thickened, or accompanied with neutrophilic granulocyte infiltration. The immediate favorable prognosis could be possible but recurrence might loom large.