A PATHOLOGICAL AND
CLINICAL STUDY OF MESANGIAL PROLIFERATIVE GLOMERULONEPHRITIS IN CHILDREN
Pan K-L1, Fu R1, Niiu X-Q1,
Chen W2, Zhang J3, Liu Y-F3
1 Department of Pediatrics, Xijing
Hospital, Fourth Military Medical University, Xian, China
2 Department of Nephrology, Xijing
Hospital, China
3 Department of Pathology,
Preclinical Medicine School, China
Objective: To probe the relations of mesangial proliferative
glomerulonephritis (MsPGN) in children and the accompanied infectious
vasculitis with nephrotic syndrome.
Method: Comparative analysis of the pathological and clinical data of 59
children suffered from MsPGN were carried out to determine the degree of
the disease, the presence of immunoglubulin deposit and the occurrence of
vasculitis.
Results: 1) 36.36% of the primary MsPGN cases were induced by infections
of various types, the respiratory track infection being the most common
inducer. 2) The degree of seriousness of the clinically diagnosed MsPGN
varied. Mild MsPGN mostly complicated with primary glomerulus, while
moderate and severe cases complicated with secondary glomerulus
(P<0.05). 3) Inflammation of renal interstitial small vessels was also
noticed, but there were significant differences among the 7 groups
(P<0.05), the group of hematuresis having more cases of inflammation. 4)
The positive rate of immunohistochemisty examination totaled 54.2%, mosly
IgG positive.
Conclusion: MsPGN proved to be the most common nephrotic troubles among
children pathologically. IgG deposit appeared mainly in the mesangial area
which was complicated with infectious vasculitis. Interstitial small
vessels were slightly or moderately thickened, or accompanied with
neutrophilic granulocyte infiltration. The immediate favorable prognosis
could be possible but recurrence might loom large.