STUDY
ON THE RELATIONSHIP BETWEEN HUMAN PARVOVIRUS B19 AND CHILDREN'S CONNECTIVE
TISSUE DISEASES
CAO
Y-H, ZHANG G-C, ZHANG G-Y, XU D-L
Xijing Hospital, Fourth Military
Medical University, Xian, China
Objective: To study the
relationship between human parvovirus B19 （B19） and children's
common connective tissue diseases.
Methods: Nested PCR
was used to detect B19-DNA in 95 children with connective tissue diseases.
B19-IgM in some patients was detected by ELISA.
Results: Thirty-three （34.74%） of 95
patients in the case group and
2 （4%） of 50 healthy children
in the control group were positive for B19-DNA（P<0.01）. Eleven （22%） of 50
patients in the case group and none of the children in the control group
were positive for B19-IgM（P<0.01）. There was
no difference in the positive rates of B19-DNA and IgM among the five types of children's common connective tissue diseases（P>0.05）. Of 50 patients in the
case group whose B19-DNA and IgM were tested, 10 were positive for both
B19-DNA and IgM, while another
7 were only positive for B19-DNA and 1 for B19-IgM.
Conclusion: The
B19 infection rate of Chinese children with common connective tissue diseases is
higher. There is a close relationship between B19 and children's common
connective tissue diseases, B19 may be one of the main pathogenic agents of
these diseases.