BASIC FIBROBLAST GROWTH FACTOR PROTECTS THE NEONATAL BRAIN AGAINST HYPOXIC-ISCHEMIC DAMAGE

Xin Y, Han YK, Gao H, Sun GL

The Second Clinical College of China Medical University, Shenyang, China

 

Objective: To investigate the protective effects of basic fibroblast growth factor (bFGF) on hypoxic-ischemic brain damage (HIBD) in neonatal rats.

Methods: HIBD model was established in 63 Wistar rats of 7-day-old, the macro- and micro-morphological features in HIBD rats treated with bFGF were compared with those in HIBD rats without the treatment of bFGF.  

Results: Two weeks after hypoxic-ischemia (HI), the brain tissue at the carotid ligation lateral of neonatal rats showed severe injury. The incidences of brain atrophy, malacia and cavitation were 73.3%, 60.0% and 26.7% respectively. The treatment with bFGF could greatly relieve the cerebral injury of HI, and reduce the incidences of brain atrophy and malacia to 31.0% and 24.1%, respectively (P<0.05). The ultra-structure of neurons, endothelial cells and glia in hippocampus also degenerated greatly following HI, while it could be relieved with the treatment of bFGF when compared with the control group.

Conclusion: bFGF appeared globally neuroprotective effects on the developing brain in a neonatal model of HIBD, and its mechanisms might be associated with promoting the recovery of the neurons.

 

 

 

 
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