文本框: STUDY OF 13C-UREA BREATH TEST IN THE DIAGNOSIS OF HELICOBACTER PYLORI INFECTION IN CHILDREN  
JIA Liying, DONG Senghuan, ZHANG Yanling, et al
Department of Gastro-enterology, Capital Institute of Pediatrics, Beijing, China

Objective: To evaluate the reliability of 13C-urea breath test (13C-UBT) in the diagnosis of Helicobacter Pylori (HP) infection in children.  
Methods: By using 13C-UBT the authors studied 435 children with Alimentary symptoms. At the same time 41 of those with serious symptoms  were examined with gastroscopy and antral  biopsis were obtained.for  Warthin-Starry stain (W-S stain) and rapid urease test (RUT). The tally proportion of 13C-UBT against gastroscopy, the sensitivity, specificity,  positive predictive value (PPV) and negative predictive value (NPV) were calculated. At the same time 300 cases were examined serum HP-IgG antibody, 146 of those performed 13C-UBT.  The tally proportion of 13C-UBT against serum HP-IgG antibody were calculated. 
Results: The tally proportion of gastroscopy against 13C-UBT were 90.24%. The sensitivity specificity PPV and NPV were 75%, 100%, 100%, and  86.2% respectively. The tally proportion 0f 13C-BUT against serum HP-IgG antibody were 63.1%. 
Conclusions: 13C-UBT is a method with higher sensitivity and highly specificity. As a noninvasive method it is reliable for detection of HP infection in children.

[key words] Helicobacter pylori 13C-urea breath test Urease
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