文本框: THE EFFECTS OF IONIC HIGH-OSMOLALITY CONTRAST MEDIUM ON RENAL FUNCTION IN CHILDREN Chen Chaoying, Chen Dakun, Cao Li, Capital Institute of Pediatrics, Beijing, China Objective: The aim of this prospective, randomized, controlled study was to evaluate the side effect of ionic, high-osmolality contrast media on the renal function and the effects of hydration on the prevention of contrast associated nephropathy (CAN) in children. Methods: 30 children were randomized to allocate into two groups. 15 children in the hydrate group (HG) received 20 ml/kg intravenous infusion of normal saline immediately after exposure of contrast media, while 15 children in the non-hydrate group (NHG) without infusion. Results: Before the exposure of contrast media, the baseline value of Bun, Cr and Ccr was comparable between two groups. After the administration of contrast media, the HG had a higher Ccr (89.34±13.22 ml/minvs 70.90±8.81 ml/min, P<0.05) and lower Cr (0.564±0.07 mg/dl vs 0.656±0.133 mg/dl, P<0.05) compared with NHG. In HG, Cr and Ccr was unchanged before and after the exposure of contrast media, while in the NHG the Cr increased from0.6±0.09 mg/dl to 0.656±0.133 mg/dl (P<0.05) and Ccr decreased from 95.87±14.4 ml/min to 70.90±8.81 ml/min (P<0.05). No patient developed CAN in the HG but 4 patients in NHG fulfill the diagnostic criteria of CAN. 2 of 3 patients with baseline Cr > 0.7 mg/dl developed CAN after the exposure of contrast media. Conclusion: The results showed that the incidence of CAN is 26.7 % in children and when baseline Cr is more than 0.7 mg/dl, the incidence increased dramatically. The CAN could be prevented effectively by hydration immediately after the administration of contrast media. 0960