文本框: EFFECTS OF EXTRACORPOREAL MEMBRANCE OXYGENATION ON BLOOD SYSTEM Li J, Song GW, Fan LK, et al Capital Institute of Pediatrics, Beijing, China Objective: To observe the effects of extracorporeal membrane oxygenation (ECMO) on blood system. Methods: Thirteen healthy sheep were enrolled in this experiment. Standard procedures of veno-arterial ECMO were used. The platelet count, platelet aggregation, PT, APTT and WBC were evaluated before experiment, pre ECMO (i.e. 30 minutes after intravenous administration of 200 U/kg of heparin) and post ECMO. Results: At one hour from the beginning of ECMO, platelet count decreased from 259±121 to 139±71 ´109/L and remained at low level (130±51´109/L) at ECMO 3 hrs. The significant decline of collagen and ADP induced platelet aggregation was observed at ECMO 3 hrs, which was from 41.5±13.1% and 40.1±9.8% at 30 min after heparin administration to 31.5±11.2% and 31.3±8.1%, respectively. PT and APTT were remarkably prolonged at ECMO 1h in comparison with that before experiment and 30 min after heparin administration. At one hour of ECMO, WBC decreased from base level (12.1±4.1´109/L) to 4.0±3.0 ´109/L (p<0.01) and then remained at low level during ECMO. All the changes mentioned above returned to normal within 24hrs post-ECMO. Conclusion: Transient decline of platelet and white blood cell count and abnormality of platelet aggregation and coagulation occured during ECMO. They all returned to normal within 24 hrs post-ECMO. 0970