文本框: EFFECTS OF SURFACTANT REPLACEMENT THERAPY ON LUNG FUNTION IN NEONATAL RESPIRATORY DISTRESS SYNDROME Li J, Song GW, Gan XZ, et al Capital Institute of Pediatrics, Beijing, China Objective: To observe the effects of pulmonary surfactant (PS) replacement therapy on lung function in neonatal respiratory distress syndrome (NRDS). Methods: 10 NRDS infants were treated with Curosurf. The changes of the blood gases, lung aerovation and lung thorax dynamic compliance after therapy was observed. Results: After 30 min of the administration of Curosurf, significant increase was seen in PO2 (from 6.1±1.8kPa to 18.2±7.4kPa) and in a/APO2 (from 0.12±0.04 to 0.37±0.15). The high levels of PO2 and a/APO2 remained until following 3 days and were significantly different from the levels before the treatment (p<0.05). After 6 hrs of the administration, PCO2 decreased from 7.06±1.75kPa to 5.01±0.79kPa (p<0.05); chest X-ray showed an obvious improvement in lung aerovation, and lung thorax dynamic compliance rose significantly from 2.8±0.42ml.kPa-1.kg-1 to 3.42±0.58ml.kPa-1.kg-1 (p<0.05). The lung thorax dynamic compliance still remained at high level after 24 hrs of the medication. Conclusion: Curosurf could improve lung oxygenation and ventilation, lung aerovation and lung thorax dynamic compliance effectively in NRDS infants. 0971