文本框: THE GENETIC SUBTYPE OF 3 CASES WITH FANCONI ANEMIA Peng GJ, XieY*, Wang KY, Xia H*, Hu Q, Chen YH*, Liu SY, Zhang LQ Tongji Hospital,Tongji Medical College, Huazhong University of Science and Technology, Wuhan,China *People`s Hospital of Hubei Province, Wuhan, China Objective: To explore the clinical manifestations and genetic subtype of patients with Famconi anemia (FA). Methods: 3 children with FA were investigated clinically; Mitomycin C (MMC)-induced chromosomal breakage tests of the peripheral blood lymphocytes from 3 cases were done; The genetic subtype of FA was done by cell fusion and complementation analysis. Results: 3 cases with FA were all exhibited bone-marrow failure, congenital multiple malformation.MMC-induced chromosomal breakages in peripheral blood lymphocytes from 3 cases were much higher than those in healthy controls, and their subtypes are group A gene (FANCA). Conclusion: FA is an autosomal recessive disease characterized with dysfunction of bone-marrow hematopoiesis, congenital multiple malformation and not good effect of treatment. Our study indicated that peripheral blood lymphocytes from 3 cases with FA were hypersensitive to DNA cross-linking agent (MMC); Genetic subtype may offer valuable information for gene therapy, and improve the treatment of the hereditary disease. 0973