文本框: EFFICACY STUDY OF A 3 MONTH PREVENTIVE TREATMENT WITH RIBOSOMAL DERIVATIVES (RIBOVAC Ò) IN CHILDREN WITH RECURRENT RESPIRATORY INFECTIONS ATTENDINA DAYCARE CENTER Castañeda NJ, Chávez RR National Institute of Pediatrics, Mexico City，Mexico Objective: Recurrent respiratory infections are a problem faced daily in pediatric practice, especially in children attending daycare centers. Decrease in the number of infections, days with fever, use of antibiotics, number of missed school days and parents’ missed work days were evaluated at the end of ribosomal derivatives administration of K. pneumoniae, H. influenzae, S. pyogenes, S. pneumoniae in children attending daycare centers in Mexico City. Methods: A prospective, longitudinal, observational and descriptive study was designed. 151 children attending a daycare center of southern Mexico City were studied. Number of infections, days with fever, use of antibiotics, missed school days or parents’ missed work days were analyzed. An envelope of ribosomal derivatives (RIBOVACÒ) was given daily in the morning in fasting conditions during four days, with a three day interval during three weeks, repeating the treatment during four days only one week for two months. At the end of this schedule the same written questionnaire answered on admission was completed again. Results: After the medication, a decrease in the number of infections was noted (p<0.001), days with fever (p<0.001), use of antibiotics (p<0.001), missed school days (p<0.05) and parents’ missed work days (p<0.05). Conclusion: The use of ribosomal derivative modulators is useful for management of recurrent respiratory infections in children. 0979