NEPHROTIC SYNDROME IN CHINESE CHILDREN
Yang JY
First Hospital, Peking University,
Beijing, China
Nephrotic
syndrome (NS) is a common renal disease in Chinese children. It accounted
for 31% of the hospitalized children with renal diseases. A pathological
study of 849 cases showed that: minimal and minor change 203 cares (24.0%)
MsPGN 264 (31.1%), IgM-nephropathy 108 (12.7%), FSGS 81 (9.5%), MN 42
(4.9%), IgA-nephropathy 39 (4.6%) MPGN 37 (4.4%) etc.
Most nephrotic patients showed
normal renal function, but acute deterioration of renal function occurred
occasionally. ARF may be resulted from:
1.
Persistent hypovolemia and renal
hypoperfusion: it may be precipitated by vomiting, diarrhea, injudicious
diuretic therapy or abrupt withdrawing the steroid.
2.
Bilateral renal vein thrombosis.
3.
Idiopathic reversible renal
failuse. It is ususlly associated with prominent edema and hypoalbuminemia.
Pathologically it showed mainly an interstitial edema.
4.
Tubulointerstitial nephritis. It
is usually caused by some drugs (antibiotics, diuretics, non-steroid
anti-inflammatory drugs). Recently an Aristolochic acid nephropathy (AAN) caused
by some Chinese medicine herbs was reported.
5.
Crescent formation in addition the
original glomerular lesion.