Text Box: HYPERLIPIDEMIA CONTRIBUTES TO LIVER DAMAGE IN CHILDREN WITH NEPHROTIC SYNDROME: LIVER AND RENAL PATHOLOGICAL EXAMINATION OF 10 CASES Liu GL, Gao YF, Xia ZK, et al Department of Pediatrics, Nanjing JinLing Hospital, Nanjing, China Objective: To study the extent of liver damage caused by hyperlipidemia in children with nephrotic syndrome, liver and renal biopsy were performed simultaneously in 10 patients from 1998.5 to 1999.9 in-clinics. Methods: The histological samples of renal and liver were examed by rountine microscpic, electroscopic and immunofluorescence examinations. Results: All the patients had abnormal liver histologic changes, focus fatty degeneration in liver tissue were found under microscopic examinations,light fatty degeneration were found under electroscopic examinations. Renal pathological changes were as below: mesangial proliferative glomerulonephritis in 8 cases, focus segmental glomerulosclerosis in 2 cases. Conclusions: Lipid metablism disorder injurys to renal tissue, but also to liver tissue, even in turn increses lipid metablism abnormal. It is believed that hyperlipidemia is related to increse synthesis of lipid and apolipoprotein, and to reduce catebolism of chylomicron and very low density lipoprotein. It should be further study between these changes and hypoalbuminemia or lower plamse oncotic pressure. 1002