EFFECTS OF SMALL DOSES OF CORTROSYN DEPOT COMBINATION WITH VITAMIN B₆ AND LAMOTRIGINE FOR THE TREATMENT OF INFANTILE SPASMS

Pu S-X¹, Zhou W²

¹ The Second Hospital, Guangzhou Medical College, Guangzhou, China

² Guangzhou Children’s Hospital, Guangzhou, China

Objective: To study the effects and safety of small doses of Cortro-syn Depot combination with Vitamin B6 and Lamotrigine for the treatment of infantile spasms.

Methods: Combination therapy consisting of low-dose synthetic ACTH-Cortrosyn Depot [0.01～0.015 mg/(kg•d)] and high-dose Vitamin B₆ [20-50 mg/(kg•d)] and Lamotrigine was prescribed in 25 children with infantile spasms.

Results: As of 1 month after discontinuing the Cortrosyn treatment, 22 of the 25 (88.0%) patients had experienced no seizures. The mean interval until seizure control was achieved was 3.7±2.0 days (range 1.5～6.0 days) after the start of treatment with Cortrosyn. 25 patients have been monitored for a mean of 20.2±14.1 months (range 6～30 months), 2 patients (9.1%) have had recurrences of infantile spasms, and no patients had other types of seizures. 9 of the 25 patients (36.0%) have had transient symptoms of increased irritability and excitability, 7 of the 25 patients (28.0%) manifested hyperorexia, but none of the patients develop more serious side effects.

Conclusion: Combination therapy with low-dose Cortrosyn Depot and high-dose Vitamin B₆ and Lamotrigine appears to be a more effective and safer therapy with very few side effects and lower recurrence for the treatment of infantile spasms.

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