A STUDY ON TREATMENT OF LARGE DOSE
OF DEXAMETHASONE IN NEONATES WITH HYPOXIC ISCHEMIC ENCEPHALOPATHY
Liao Z, Fu S.T, Bao Y, et al.
Department of
Pediatrics, The Second Mumicipal Hospital of Chengdu, Chengdu, China
Objective: To study the
therapeutic effects of different dexamethasone in newborn inflants with
hypoxic ischemic encephalopathy (HIE).
Methods: 59 cases with HIE
were divided into two group: the HIE dexamethasone large-dose treatment
group (n=29) and low-dose treatment group (n=30). The concentration of
plasma lipid peroxidation (LPO), nitric oxide (NO), cortisol and
adrencorticotrophic hormone (ACTH) was measures and neonatal behavioral
neurological assessment (20-item NANB) was evaluated on day 1 and 4 of
life, respectively.
Results: The plasma levels
of LPO, NO and PTC were significantly higher in HIE (P<0.05 or
P<0.01) than those in normal group. After treatment, these plasma levels
were obciously lower in high-dose damethasone treatment group than those in
low-dose group (P<0.01), but the concentration of ACTH was normal.
Moreover, the scores of 20-item NANB had an obvious increase in high-dosse
group (P<0.05). Conclusion: The results
indicated that large dose dexamethasone within a short period is effective
method in treatment of meonates with HIE and could not cause disorder of
cortisol level and inhibit the function of supradrenal cortex.