EARLY
MONITOR OF NEONATAL OF VITK LACD WITH PIVKA-ⅡCHECK AND INTERVENTION
Guo J，Sun Y-E，Qin Y-Z，et al
Department of Neonatology，Tianjin Children’s Hospital, China
Objective: To realize the status of
neonatal in VitK deficiency and study the way of prevention and treatment.
Method: Detecting the content of
plasma PIVKA-Ⅱin
hospitalized neonatal (≤5 days)
with ELISA, positive result of PIVKA-Ⅱ
indicating deficiency of VitK. VitK in two deferent doses were given to the
cases with lacking of VitK or complicating bleeding. The change of PIVKA-Ⅱ after VitK input was
monitored.
Results: In 214 hospitalized
neonatals, 96 (44.86%) cases were found with PIVKA-Ⅱ positive, complication with bleeding in
positive group was higher than negative ones, the deference is significant.
Two deferent doses of VitK were given to the positive group, and plasma
PIVKA-Ⅱlevel were checked after
60-84 hrs, the effective rates were 70% and 80% respectively, no deference
in the two doses groups was found.
Conclusion:
Detection of PIVKA-Ⅱ in
neonatal can reflect the status of VitK lack, VitK injection can
effectively prevent neonatal bleeding, 1mg of VitK is recommended.