Text Box: STUDY ON WEBER-CHRISTIAN PANNICULITIS IN CHILDREN: IT IS RELATED TO SOME SPECIFIC DISEASES Wu FQ, Han TX, He XH Beijing Children's Hospital, Beijing, China Objective: To investigate whether Weber-Christian panniculitis in children is a kind of specific disease or nonspecific disease. Methods: We studied 16 cases diagnosed as Weber-Christian panniculitis baseing on clinical manifestations, routine pathological and immuno-histochemical methods, relationship laboratory examination and follow-up. Result: A variety of distinctive diseases entities were recognized in 16 children include seven subcutaneous panniculitis-like T-cell lymphoma (SPTCL); systemic lupus erythematosis (SLE ), systemic cryptococcosis, inflammatory bowel disease (IBD) and malignant histiocytosis in one patient each; tuberculosis infection and streptococcus infection were diagnosed in two children each. One¡¯s cause is unclear. 13 of 16 children were under follow-up. Tuberculosis or streptococcus infection was cured with antibiotic or antituberculotic. SLE and IBD are stable with regular treatment. One SPTCL are unstable with unregular prednisone. Three SPTCL, one malignant histiocytosis and one systemic cryptococcosis died. Conclusion: Weber-Christian panniculitis is not a kind of specific disease. It is nonspecific subcutaneous inflammation. A variety of distinctive diseases are associated with Weber-Christian disease. We proposed that the Weber-Christian panniculitis should be abandoned and that more specific diagnosis should be made on the base of pathogenoesis or causes. 1065