Text Box: CHANGES AND SIGNIFICANCE OF ANTERIOR FONTANEL PRESSURE AND BLOOD PRESSURE IN 24 HOURS OF SICK NEONATES Wang QH, Yang YJ Department of Neonatology, Xiangya Hospital of Central South University, Changsha, China Objectives: The present study was undertaken to investigate the method offf AFP measurement, find out the rhythm of AFP and blood pressure in 24 hours. Method: Twenty-five neonates were divided into non-intracranial disease (NID), slight asphyxia (ASP) and perbilirubinemia (HBE) three groups. AFP and mean arterial pressure (MAP) in 24 hours were analyzed. All patients had not received dehydrant therapy in clinical. Results: ① The levels of AFP in all patients ranged from 1 mmHg to 10 mmHg. ② In the AFP variables in 24 hours, the level is highest at 10 am,whereas which is lowest at 1am～ 2 am. ③ The AFP is not increase in neonates of slight asphyxia.④ AFP in neonates age between 2 ～ 7 days is low level.⑤ There are no correlation among AFP and weight, sige of fontanel, and MAP. Conclusions: ①The appreciated time for AFP measurement is at 10 am in one day. ② The AFP of neoates with slight asphxia, non-intracranial disease and hyperbilirubinema do not increase obviously. 1087