LOW DOSE
CYCLOSPORIN A TREATMENT IN GENERALIZED PUSTULAR PSORIASIS
Kilic SS,
Hacimustafaoglu M, Celebi S, Kose H
Department of
Pediatrics, Uludag University Faculty of Medicine
Bursa, Turkey 16059
Objective: Generalized pustular
psoriasis is a rare form of psoriasis, also rare in children. Methods and
Results: Three patients with generalized pustular psoriasis were presented,
two of whom patients were a sister and a brother and whose grandfather has
also had pustular psoriasis. Lesions consisted of pustular erythematous
scaly follicular papules located on the trunk, scalp and extremities. The
pustules in some areas coalesced to form lakes. Histological examination of
several biopsy specimens revealed the changes of pustular psoriasis which
were parakeratosis, elongation of the ridges and deep, spongioform pustules
and Munro abscess. All patients have been treated with cyclosporin A for
periods varying from 2-12 months. The dose ranged from 1-2 mg/kg/day.
Conclusions: Clearance of psoriatic
lesions occured after 2-4 weeks of starting therapy.