Text Box: PRILIMINARY RESEARCH ON MECHANISM OF L-TYPE CALCIUM ANTAGONIST NIFEDIPINE ON TREATING PRETERM LABOUR Zhang Rongrong, Yang Zujing, Jin Mingfei, Pan Jun Departmant of Obstetrics & Gynecology, Xinhua Hospital, Shanghai Second Medical University, Shanghai, China Objective: To monitor the complex calcium oscillations in intracellular Ca2+ in first-passage human myometrial cells after oxytocin stimulation using lasal confocal microscope. To take a preliminary research on mechanism of L-type calcium antagonist in treating preterm labour Methods: After primary cell culture of human myometrial cell.using desmin and action to assay.we monitor calcium changes for 90 minutes utilizing lasal confocal microscope after adding oxytocin and nefidipine. Results: Calcium wave represents one way to encode cell signal induction. Obvious calcium oscillations occurred after adding oxytocin but calcium waves are irregular and not synchronizable.nefidipine can oppress calcium oscillations only before the occurance of calcium wave. Conclusions: Nifedipine has some limitation on therpying preterm labour.this implys that there may be other calcium channel or subunites on myometrial cell membrane. 1111