Text Box: MULTIPLE ORGAN DYSFUNCTION SYNDROME IN NEONATAL ASPHYXIA Cui LW, MiY, Zhang WS, Bai XZ First Medical College, Harbin Medical University, Harbin, China Objective: To study the clinical features of multiple organ dysfunction Syndrome (MODS) in neonatal asphyxia and to analyze the relation between MODS and clinical factors including perinatal factors and blood calcium. Methods: All blood calcium of 81 cases in sixteen nonashyxia newborn infants (control) and sixty five asphyxia newborn infants was tested with Beckman Synchrone CX5. Results: (1) The incidence of organ involvement after asphyxia was 87.7% and central nervous system involvement (69.2%) was most, and the incidence of MODS was 64.6%. The frequency of MODS in severe asphyxia (85.7%) was obviously higher than in mild asphyxia (48.5%) (p<0.05), and the mortality of severe asphyxia (28.6%) was higher than that of mild asphyxia (2.7%) (p<0.01). The mortality of more than three organs involvement (90%) was obviously higher than that of three organs involvement (4.8%) (P<0.01). (2) The incidence and severity of MODS after asphyxia were related to Apgar score (P<5 at minutes) and blood calcium instead of gestational age, meconium-stained amniotic and intrauterine asphyxia (p<0.05). Conclusion: Asphyxia is the main reason for MODS in neonates, and it is necessary to protect organs after asphyxia. The changes of multiple organs involvement and blood calcium are the secondary marker to evaluate the situation and prognosis of neonates with MODS. 1118