Text Box: INFLUNCE OF TANAKAN ON HYPOXIC-ISCHEMIC BRAIN DAMAGE AND SUPEROXID DISMUTASE MALONDIALDEHYDE IN NEONATAL RAT Jiang M-L, Li R-L Second Hospital of Xi’an Jiao Tong University, Xi’an, China Objective: Efficacy of tanakan,Ginkgo biloba extract,in neonatal rat hypoxic-ischemic brain damage. Methods: Hypoxic-ischemic was induced in rat pups by performing a delayed cesarean secton on the last day pregnant Sprague-Dawley rats.Tanakan (one kind of Ginkgo biloba extract) the sixteenth day SD female rats were treated with 100mg/kg added to the pups for 2 days. Then they were performed the same operation.Litters delivered by cesarean section without producing hypoxic-ischemic were used as controls. We examine superoxide dismutase (SOD) activity and malondialdehyde (MDA) content in the pup brain tissues. Results: The activity of SOD s significant reduction in hypoxic-ischemic model rats (p<0.01). Pretreatment or therapy with Tanakan pups showed a signifinant increase in SOD activity. And Sod activity in pretreatment pups is higher than therapy with it. The level of MDA is significant increase in hypoxic-ischemic model rats (p<0.01). Pretreatment or therapy with Tanakan pups showed a significant reduction in MDA content.And MDA levels in pretreatment pups is lower than therapy pups. Conclusion: Tanakan can protect the neonatal brain when hypoxic-ischemic brain damage happens.And pretreat with tanakan is better than therapy with it. 1127