Text Box: CLINICAL SIGNIFICANCES OF ISOTYPE－SPECIFIC ANTIBODY IGA TO MYCOPLASMA PNEUMONIAE INFECTION Cao L－F, Lu W－R, Mao H－Y et al Ren Ji Hospital, Shanghai Medical University, Shanghai, China Objective: To explore to clinical signifi cances of isotype-specific antibody IgA to Mycoplasma pneumoniae infection. Methods: Using ELISA and pellet agglutinated methods, dertermination of MP-IgA and MP-IgM antibody for 296 cases with broncho pneumonia and 57 cases of followers. Results: The changes of MP-IgA antibody were shown no difference with MP-IgM. The positive rate rise along with the efficacy of MP- IgM and course of disease related obviously to the infection of respiratory tract. The efficacy of Mp-IgM was declined after three months, the part of that sustained longer for children with infection of respiratory tract. Conclusions: The deternimation of isotype-specific antibody IgA to mycoplasma pneumoniae had profound important significance, to rising the susceptibility and specificy for diagnosing the infection of mycoplasma pneumoniae. 1132