Text Box: ERYTHROMYCIN AND CISAPRIDE TREATING NEONATES WITH FEEDING INTOLERANCE Huang Y, Shao X-M, Zeng J-H，et al. Children’s Hospital, Fudan University, Shanghai, China Objective: To investigate the effects of erythromycin and cisapride promoting neonatal gastrointestinal motility and improving neonatal feeding. Methods: Studying 41 neonates suffering from feeding problems hospitalized during the year Nov 1997 to Feb 1999. Erythromycin 3-5mg(kg×d) ivgtt and cisapride 0.2-0.3ml/kg, tid by oral were used in our study. Gastroesophageal scintigraphy and radioimmuno assay were measured before and after the interferon. Results: 27 neonates were treated with erythromycin for 7.8±2.2days, after that gastric emptying rate at 60’(GE60%) increased from 22.9±12.6% to 38.7±17.1%, reflux index (RI) decreased from 16.9±9.4 to 8.1±5.7, p<0.001; plasma motilin increased significantly (from 583.2±253.1 pg/ml to 907.5±301.1 pg/ml, p< 0.001) but serum gastrin didn’t change greatedly (52.8±12.9 pg/ml vs 58.7±20.4 pg/ml, p>0.05). 14 neonates took cisapride for 9.4±2.2d, GE60% increased from 26.2±14.7% to 40.0±17.4%, RI decreased from 17.3±11.4 to 7.2±3.5, p<0.01. But blood level of gastrin and motilin didn’t change significatly. After treatment, there were no difference of the volume of milk between the two groups (176.2±49.4 mg/（kg×d) in erythromycin group and 197.5±35.8 mg/（kg×d） in cisapride group, p>0.05）. As compared with GE60%, RI and serum gastrin there were no difference between the two groups, but after infused with erythromycin, plasma motilin increased greatly. There were no obvious side effects of the two drugs in this study. Conclusion: Erythromycin and cisapride can promote neonatal gastro-intestinal motility and improve their feeding. How to choose the drugs depends on the specific situations. 1162