The
Influence of Blood Lead Levels on Rickets
Zhang
JF, Li WC
Xinhua Hospital, Shanghai, China
Objective:
This study was designed to better determine the effect of lead on rickets. 86
children were registered in this study. These children were studied from 6
months to 3 years of age. 45 cases of rickets, and 41 well-defined control
group of young children were among them. We studied the blood lead level
(BPb), 25-hydroxyvitamin D (25OHD), calcium (Ca), phosphorus (P), magnesium
(Mg), alkaliphosphatase (ALP) and wrist X-film, respectively.
Methods:
Blood samples (6ml) were taken for the measurement, including whole
blood lead and serum total calcium, phosphorus, magnesium, 25OHD. Serum
25OHD was measured by a competitive protein binding assay (rat serum as
binding protein). Lead in whole blood was measured by Atomic Absorption
Spectrometry (graphite stove). In addition, the laboratory participates in
the Centers for Disease Control. Ca, P, Mg, ALP were measured with
conventional methods.
Results:
Most of the children with rickets in this study had elevated blood lead
concentration, and the results had statistic significance (p<0.01
t=8.0208). The blood lead levels were no statistic significance between
difference sexes in those children of 6 months to 3 years old(p=0.0689); No
correlation was found between the blood lead levels and 25-hydroxyvitamin
D(P=0.1873); The blood lead levels of children in Urumqi were higher than
those of other areas of our country.
Conclusion:
Blood lead levels influence the rickets; 25OHD concentration of rickets is
lower than those children of control group. The sex is not related with the
blood lead levels of children within 3 years old; The blood lead levels do
not affect on 25-hydroxyvitamin D; The blood lead levels of children in
Urumqi are higher than those of other areas in our country.