HIGH-FREQUENCY
OSCILLATORY VENTILATION COMPARED WITH CONVENTIONAL IN PRETERM INFANTS WITH
RESPIRATORY DISTRESS SYNDROME
Ding GF, Liu F, Wang DH
Peiking Union Medical
College Hospital, Beijing, China
Objective: To compare
high-frequency oscillatory ventilation (HFOV) and intermittent positive
pressure ventilation (IPPV) as a primary ventilation mode in preterm
infants with respiratory distress syndrome (RDS).
Methods: Seventeen premature
infants (gestational age <34 weeks, mean 30.16±3.13weeks) with at least grade II RDS confirmed by
chest X-ray, randomly assigned to HFOV (n=9)or IPPV(n=8). No differences
were found between the study group with respect to demographic data or the
severity of RDS. Respiratory pressures were reduced when the infants oxygen
requirement had reached a concentration of inspired oxygen 0.6.
Results: three infants in the
HFOV group died, whereas two patients in the IPPV group died, and one was
switched to HFOV. No differences were found in gas exchange or ventilator
support in the first 72 hours (included Fio2, MAP, PO2,
PCO2). No differences were found between the groups in
intracranial bleeding and air leak. No differences existed in heart rate
and blood pressure.
Conclusion: HFOV, as a primary
ventilation mode in premature infants with RDS, is as safe and efficacious
as conventional ventilation.