NEW
PATHOGENETIC MECHANISMS OF ACUTE BRONCHI-PULMONARY PATHOLOGY AT CHILDREN
Pikuza O., Zakirova A.,
Shoshina I., Petrova G.
The
Kazan medical university, Tatarstan, Russia
Objective: the deployment of new pathogenetic mechanisms of
acute bronchi-pulmonary a pathology, in which clinical current for the last
years is observed significant transformation.
Methods: 255 children in the age of from 1 till 15 years are
examinated, at which the parameters of colonizations resistanse of a oral
cavity, concentration of complement component С3 and condition of cell
membranolyse (malonic dialdehyde, 5`-nucleotidase) were investigated.
Results:
the decrease of oral streptococci adhesive activity, closely interconnected
with severity of lesions of bronchi-pulmonary system is established. In all
children with parameters natural colonization at £1 were registered severy forms of process. On
background of inflammatory lesion of lung is marked reduction of complement
С3-component up to 0.75±0.08 g/L, and at a level it 0.37 g/L and lower
pneumonia had the complicated current at all children. In parallel to
severity of inflamatory process in lung were changed cell membranolyses
prosess, what indicated essential increase of a level 5`-nucleotidaseup to
237.99±19.92
ncat and malonic dialdehyde up to 4,95±0,9 mmol/L.
Conclusion: the correlation between character of current of a
bronchi-pulmonary pathology at children and condition of the immune status
is established. In cases of a severity lesions of a pulmonary system is
revealed the essential decrease a parameters of colonization resistans,
complement С3-component, functionally interconnected with a condition of
cell membranolyse. Thus is marked change of these parameters in opposite
directions. The there were below levels of complement С3-component, the the
damage of membrane structures of cells was stronger.
The shown data enable to
increase effectiveness of therapy of the patients, at the expense of
adequate correction circumscribed pathogenetic changes.