CLINICAL AND PATHOLOGICAL EVALUATION OF IGA NEPHROPATHY AND HENOCH-SCHONLEIN NEPHRITIS IN CHILDREN

Jianhua Zhou , Yunqin Wang, Tongling Liu, Aixia Huang and Yujiu Kuang

Department of Pediatrics, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

 

Objective: IgA nephropathy (IgAN) and Henoch-Schonlein nephritis (HSN) were so similar that many nephrologists considered them as one disease entity. The present work is to evaluate the clinical and pathological similarity and difference of IgAN and HSN in children.

Methods: 120 hospitalized children with HSN and 32 biopsy-proved IgAN were clinically evaluated, meanwhile 32 children with HSN were renal biopsied to compare the pathological characteristics with IgAN.

Results: Although clinical similarities existed, there were still many differences in clinical and renal pathological manifestations. IgAN had no extrorenal involvement except abdominal pain, while all HSN children had purpura and about half of them had arthralgia and abdominal pain. Mesangial sclerosis were found in 42% children with IgAN, but only 6.4% in HSN ( P<0.01). Glomerular obliteration was frequent in IgAN than in HSN (35.5% vs 3.2%), while crescents and tuft necrosis more common in HSN. Thin glomerular basement membrane could be only found in 13% children with IgAN.

Conclusion: The obvious difference between IgAN and HSN didnt support that these two was one disease entity, although IgAN seems to represent the chronic stage of HSN.

 

 
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