CLINICAL AND
PATHOLOGICAL EVALUATION OF IGA NEPHROPATHY AND HENOCH-SCHONLEIN NEPHRITIS
IN CHILDREN
Jianhua Zhou ,
Yunqin Wang, Tongling Liu, Aixia Huang and Yujiu Kuang
Department of Pediatrics, Tongji Hospital of Tongji
Medical College, Huazhong University of Science and Technology, Wuhan,
China
Objective: IgA nephropathy (IgAN) and
Henoch-Schonlein nephritis (HSN) were so similar that many nephrologists
considered them as one disease entity. The present work is to evaluate the
clinical and pathological similarity and difference of IgAN and HSN in
children.
Methods: 120 hospitalized children with HSN and
32 biopsy-proved IgAN were clinically evaluated, meanwhile 32 children with
HSN were renal biopsied to compare the pathological characteristics with
IgAN.
Results: Although clinical similarities existed,
there were still many differences in clinical and renal pathological
manifestations. IgAN had no extrorenal involvement except abdominal pain,
while all HSN children had purpura and about half of them had arthralgia
and abdominal pain. Mesangial sclerosis were found in 42% children with
IgAN, but only 6.4% in HSN ( P<0.01). Glomerular obliteration was
frequent in IgAN than in HSN (35.5% vs 3.2%), while crescents and tuft
necrosis more common in HSN. Thin glomerular basement membrane could be
only found in 13% children with IgAN.
Conclusion: The obvious difference between IgAN
and HSN didn¡¯t support that these two was one disease entity, although IgAN
seems to represent the chronic stage of HSN.