NEW BONE REMODELATION MARKERS IN NEONATOLOGY
J. Garrido
Garc¨ªa; M. Molina Hoya; R. Santana Delgado; E. Narbona L¨®pez; E. M. Sena
Ruiz.
Universitary
Hospital ¡°San Cecilio¡±, Granada, Spain
Objective:
To show the
utility of these markers in neonatal age to follow the fosfocalcic
methabolism and bone formation in some special situations of neonatal age
(preterm newborns, diabetic mother´s sons¡), and their answer to
threatments or suplementary nutritional intakes.
Methods:
30 newborns whose
samples were recolected between January and March of this year. The samples
were taken from arterious and venous blood in umbilical cord and mother
blood after delibery. We study in these samples colagen I telopeptid and
procolagen I. Once we have the results, they were analized by informatic
programs to find significative differences between origin, gestational age,
weight and other markers like osteocalcine.
Results:
Using Microsoft
Excel´2000 for a<0.05: there aren´t significative
difference between procolagen and telopeptide in arterial and venous
samples. There are significative differences between the mother samples and
the samples from the newborns: the markers are very much higher in cord
samples than in the mother ones. There aren´t differences by sex, weight or
gestational age.
Conclusion:
Newborn samples
show a bigger activity of bone methabolism than in the mother ones. Both
studied markers show almost exclusively the fetal production of them due to
their big difference with mother´s blood. So they are two adequate markers
for bone methabolism in neonatal age since delibery.