CROHN'S DISEASE IN A CHILD WITH DOWN'S SYNDROME
Yamamoto M, Hori T, Nakada T,
Tachibana N, Abo W
Aomori Central Hospital, Aomori, Japan
Crohn's disease (CD) is a rare phenomenon in early childhood, with
peak incidence occurring during the second decade of life. However , it has
been reported that the incidence of CD in childhood is rising. The
association between CD and Down's syndrome(DS) , however, has rarely been
reported.
Here we report a DS patient with CD who presented with apparent
failure to thrive, low grade fever, anemia and elevations of CRP and ESR.
Colonoscopy showed fissuring and irregular ulcers at the ileocecal
region. Barium enema showed linear ulcers and stenosis at the terminal
ileum and transverse colon. Histological examination of biopsy specimens
showed chronic inflammation with ulceration including granulation.
We suggest that CD should be added to the list of complications
associated with DS, for patients who present with failure to thrive.