1287

EFFECT OF SALBUTAMOL PLUS FLUTICASONE PROPIONATE ON AIRWAY RESPONSIVENESS IN ASTHMA

Chalerat Direkwattanachai, Suwat Benjaponpitak, Cherapat Sasisakulporn

Bangkok, Thailand

Background Inhalation of salbutamol (Sal) 15 minutes prior to inhalation of corticosteroid many enhance corticosteroid delivery to the asthmatic airways.

Objective To compare the efficiency of fluticasone propionate (FP) 125 mg delivery 15 minutes after 2 puffs of Sal bid, and 250 mg FP bid in asthmatic patients.

Methods Thirty-six asthmatic patients aged 6.5 -17 (10.9 ± 2.76) years were recruited to the study. While nineteen patients were receiving FP 250 mg twice daily, 16 patients were receiving FP 125 mg after taking 2 puffs of Sal for 15 minutes, two times a day, Metered dose inhaler connecting to Volumatie^âspacer was being used for drug delivery. FEV₁, and PD₂₀ were measured at the beginning of study and 4 weeks after the treatment.

Results After 4 weeks of treatment, the statistic indicates that there is no significant difference between the two groups in term of PD₂₀ (as shown in the table). Airway reactivity was reduced by 5.1 folds in Sal + FP 250 group and 5.5 folds in FP 500 group.

Sal + FP 250*(n = 16)

FP 500**(n = 19)

FEV1 (% Predicted)

Pretreatment

Posttreatment

93.4 ± 3.5

97.8 ± 2.2

(P < 0.14)

89.5 ± 2.3

90.8 ± 1.4

(P < 0.34)

P < 0.35

P < 0.010

PD₂₀

Pretreatment

Posttreatment

23.0 ± 5.2

116.7 ± 16.9

(P< .0001)

22.3 ± 3.1

123.6 ± 17.5

(P < .0001)

P < 0.91

P < 0.78

Change

5.1 folds

5.5 folds

* Sal + FP 125 bid ** FP 250 bid

Conclusion Inhalation of FP 125 mg after 2 puffs of Sal for 15 minutes bid can reduce airway reactivity in asthmatic patients as well as inhalation of FP 250 mg bid for 4 weeks.

1287

Background Inhalation of salbutamol (Sal) 15 minutes prior to inhalation of corticosteroid many enhance corticosteroid delivery to the asthmatic airways.

Objective To compare the efficiency of fluticasone propionate (FP) 125 mg delivery 15 minutes after 2 puffs of Sal bid, and 250 mg FP bid in asthmatic patients.

Results After 4 weeks of treatment, the statistic indicates that there is no significant difference between the two groups in term of PD20 (as shown in the table). Airway reactivity was reduced by 5.1 folds in Sal + FP 250 group and 5.5 folds in FP 500 group.

Posttreatment

Conclusion Inhalation of FP 125 mg after 2 puffs of Sal for 15 minutes bid can reduce airway reactivity in asthmatic patients as well as inhalation of FP 250 mg bid for 4 weeks.

Results After 4 weeks of treatment, the statistic indicates that there is no significant difference between the two groups in term of PD₂₀ (as shown in the table). Airway reactivity was reduced by 5.1 folds in Sal + FP 250 group and 5.5 folds in FP 500 group.