PRIMARY TUMORS OF KIDNEY
IN CHILDREN
M. Caglar, G. Kale, S. Gogus, Z. Akcoren, A. Bulun,
M. Buyukpamukcu, N. Buyukpamukcu
Hacettepe University Ihsan Dogramaci Children’s Hospital,
Ankara, Turkey
Primary tumors of kidney
occupy the sixth place among childhood neoplasms. This study documents the
clinical and pathological aspects of primary renal tumors of children under
16 years of age, retrieved from the files of Pediatric Pathology Unit,
Department of Pediatrics, Hacettepe University School of Medicine in a
period of 23 years. Out of total 361 cases, Wilms tumor (WT) constituted
the majority with 298 cases. In WT, female/male ratio was 0.93 and mixed
pattern was the most common (59.8%), followed by blastemal (27.2%), stromal
(7%) and epithelial (6%) subtypes. Teratoid features were seen in one case
and anaplasia in 10 cases (3.3%). Clear cell sarcoma of kidney was the
second in frequency (6.9%) and most of these patients were younger than 5
years of age. The next most common tumors were mesoblastic nephroma (2.2%)
and malignant rhabdoid tumor of kidney (1.6%). Pathologic diagnosis of the
others in decreasing frequency were cystic nephroma, renal cell carcinoma,
cystic partially differentiated nephroblastoma, Non-Hodgkin lymphoma,
cystic nephroblastoma, malignant mesenchymal tumor and metanephric stromal tumor of
kidney.