CHRONIC RENAL FAILURE DUE TO
UROGENITALE ABNORMALITIES IN DOWN SYNDROME: A CASE REPORT Kural
N1, Dinleyici EC1, Kaya T2
Department
of Pediatric Nephrology1 and Radiology2,
Osmangazi
Faculty of Medicine, Eskisehir, Turkey
Down syndrome with renal and urogenitale
malformations were recently reported. These malformations were renal
agenesis-hypoplasia- dysplasia, renal cystic disease, hydronephrosis,
vesicoureteral reflux, posterior urethral valves, ureteropelvic junction or
ureterovesical obstruction, horseshoe kidney, bladder hypoplasia,
hypoplasia or aplasia of the uretere or urethra, prune-belly anomaly and
hypospadias. Six-year-old girl
admitted to hospital with fever during three months. On the physical
examinations, she was Mongoloid appearance and she had systolic murmurs at
the 2/ 6 degree, diastasis recti and hepatomegaly. Laboratory evaluation
revealed as pyuria, azotemia, normochrom normocytic anemia, elevated
sedimentation rate and C-reactive protein. She had diagnosed as chronic
pyelonephritis and chronic renal failure. Mild bilateral
hydroureteronephrosis was demonstrated in renal ultrasonography and bladder
diverticula with neurogenic bladder in voiding cystouretherography. She was
discharged from hospital with renal replacement therapy. In addition to
cardiologic, immunologic and endocrionologic evaluation, renal
malformations must be detected in Down syndrome patients after birth.
Conclusion to: In this report, chronic pyelonephritis with renal failure in
Down syndrome due to urinary tract abnormalities that had been lately
diagnosed.