PROSPECTIVE STUDY OF PREOPERATIVE TRANSCATHETER ARTERIAL
CHEMO-EMBOLIZATION (TACE) FOR WILMS’ TUMOR
Li MJ , Zhou YB，Shen LG, Tang HF, Tang DX
Children's Hospital, College of Medical
Sciences, Zhejiang University, Hangzhou, China
Objective: To study
the feasibility of preoperative Transcatheter Arterial Chemo-embolization
(TACE) for Wilms’ tumor.
Methods: Transcatheter
arterial chemo-embolization (TACE) were preoperative performed in 15 cases
of huge and advanced Wilms’ tumor. The embolus contained adriamycin,
iodized oil and gelatin sponge. Tumor resected 2 weeks after TACE.
Results:
After TACE the patients had fever and transitory hypertension, but no
depressed marrow, no hepatic, renal and cardiac inadequacy. Mean regression
of tumor size war 35.6%. “Downstaging” and complete necrosis of tumor were
found in some cases. The rate of tumor radical extirpation was 66.7%. Two
years survival rate was 75%.
Conclusion: TACE
could be used as preoperative therapy for advanced Wilms’ tumor. The advanteges
are lower dosage of antineoplastic drug, milder side effects and more
necrosis of tumor; the period of preoperative therapy reduced to 2 weeks.
Higher radical tumor resection rate and higher survival rate of patients.
Key words: Wilms’ tumor, transcatheter arterial
chemo-embolization (TACE)