THE STUDY OF AIRWAY
RESPONSIVENESS IN ASTHMATIC CHILDREN DURING STANDSTILL TERM
Li WZ, Li ZQ, Zhong JY
Department of Pediatrics, Guangdong Provincial People¡¯s Hospital,
Guangzhou, China
Objective: To study the airway
responsiveness in asthmatic children during standstill term and to provide
basis for the diagnosis and treatment.
Methods: The lung function and
histamine challenge were performed in 57 asthmatic children in standstill
term and FVC, FEV 1, FEV 1%, PEF, FEF 0.25-0.75%, FEF 50% were measured.
Results: Six parameters were
significantly decreased after inhalation of histamine than that before
(P<0.01). All parameters except for PEF return to the pre-experimental
condition after inhalation of bronchodilator. Histamine challerge was
positive in 50 cases (87.7%), and negative 7 cases (12.3%). Four cases were
still positive reaction after 10 months and one year under long-term
inhaled glucocorticoide control the symptom.
Conclusion: Airway
hyperresponsiveness was suggested in asthmatic children. It is very
important to control the bronchial inflammation by inhaling glucocorticoide
in early and long term. The lung function and histamine challenge were very
important for diagnosis, treatment and judgement the curative effect in
asthamtic children during standstill term.