THE IMPACT OF SOME
CYTOKINES IN PATIENTS WITH ACUTE LEUKAEMIA AND LYMPHOMA
Salama OS*; Lotfy RH**;
Shamaa SS**; Hammouda MM**, Yousef AB**
Haematology* &
Medical Oncology** Depts.
Faculty of Medicine,
Mansoura University, Mansoura, Egypt
Many
cytokines play a crusial role in the regulation of the local and systemic
immune responses, the inflammatory reactions, haematopoiesis as well as
other biological processes (Daniel et al., 1997). Numerous critical
interactions owed to the alterations of cytokines have been demonstrated in
various malignant, collagen, inflammatory and collagen diseases. The
present study aimed to through more light on the role of
granulocyte-macrophage colony stimulating factor (GM-CSF), interleukin-6
(IL-6) and interferon gamma (INF gamma) in patients with acute leukaemia
and lymphoma. This work comprised 40 patients with acute myeloblastic
leukaemia (AML), acute lymphoblastic leukaemia (ALL), Hodgkin disease (HD)
and Non-Hodgkin lymphoma (NHL) besides 10 healthy controls. In all patient
groups as well as the reference group, the serum GM-CSF, IL-6 and gamma INF
had been determined. Significant high levels of these cytokines had been
clarified in all patient groups. The role of t!
hese
cytokines and their correlation with the adopted therapeutic measures had
been evaluated.