CLINICAL EVALUATION OF THE CONNECTION OF
RECURRENT RESPIRATORY INFECTIONS AND CILIARY STRUCTURE ABNOMALITY
MaYuyan, Liu
Xicheng, Jiang Qinbo
Beijing
Children's Hospital, Beijing, China
Objective: The goal of the study
was to evaluate the incident of cilia structure abnormality in children
suffering from recurrent respiratory tract infections, and compared the
different manifestations between the primary cilia structure abnormality
and the secondary cilia abnormality.
Methods: The study population consisted
of 39 children aged 2-13 years. They were all hospitalized in Beijing
Children's Hospital with recurrent respiratory infections. Their immune
function and serum microelement was measured at first, and was normal.
Airway mucosa biopsy was performed by bronchial fibroscopy under local
anesthesia. Then respiratory ciliated cells were analyzed by electron
microscopy with a magnification of 30,000 and counted the frequency of the
cilia abnormalities.
Results: The ciliary
ultrastructure was found to be abnormal in 17 of 39 patients. Primary
ciliary dyskineia was diagnosis in 9 cases, they were all characterized as
9+2 microtubular abnormality or total absence of cilia. Secondary cilia
structure abnormality were mostly hyperplasia of squanous epithelium or
compound cilia.
Conclusions:
Through
this study, we concluded that, besides immunodeficiency and lacking
microelement, ciliary structure abnormality was an important cause of
recurrent respiratory tract infections. The incidence of ciliary structure
abnormality was underestimate .The diagnosis of primary ciliary dyskineia
requires familiarity with the clinical picture and the specific cilia
structure and function abnormality. Although the incidence of primary
ciliary dyskineia is low, but it¡¯s not rare. So primary ciliary dyskineia
should be suspected in children suffuring from recurrent respiratory tract
infection, chronic otitis media and sinusitis.