ELECTROENCEPHALOGRAPHIC
CHANGES AND THEIR RELATION TO COGNITIVE FUNCTIONS, BEHAVIOR AND OR
PSYCHIATRIC DISORDERS IN DOWN SYNDROME
Eman
A M Zaky*, Howida El-Gebaly**, Saffia Effat***
Pediatric
Department, Faculty of Medicine, Ain Shams University, Egypt
**Medical
Department, Institute of Postgraduate Childhood studies, Ain Shams
University, Egypt
***Psychiatry
Department, Faculty of Medicine, Ain Shams University, Egypt
Objective: The
current study was conducted to investigate the electroencephalographic
changes in an Egyptian sample of DS patients and their relation to the
cognitive abilities as well as the manifestations of psychiatric and or
behavior disorders of those patients. Methods: To fulfill the goal of the study it
enrolled 44 Egyptian DS patients; 30 females and 14 males. Their ages
ranged from 3 mo to 7 yrs with a mean age of 2.85¡À1.08 yrs. Clinical fits
were reported in 31.82%of studied patients. Twenty healthy children of
comparable age and sex were included as controls. Full history taking,
thorough clinical examination, family pedigree construction, IQ assessment,
diagnosis of behavior and or psychiatric disorders using Behavior Check
List and DSM IV criteria, and
EEG recording were done for all included children. Results: Disruptive behavior and mood
disorders were reported in 22.73% and 50% of studied patients respectively
compared to none of controls (p >0.05, <0.01 respectively).
Inattentive type of ADHD was diagnosed in27.27% of studied DS cases
compared to 5% of controls (p>0.05) while hyperactive type of ADHD was
diagnosed in 40.91% of enrolled patients and none of controls (p<0.05).
EEG changes were reported in 54.54% of studied patients (of them, 27.27%
experienced clinical fits while 27.27% did not) compared to 20% of controls
(p>0.05). There was neither statistically significant association
between the existence of EEG changes nor their types and the degree of
mental retardation of studied patients, their psychosocial dysfunction
score or the concomitant type of behavior and or psychiatric disorder. On
the other hand, focal epileptogenic discharge was significantly associated
with lower IQ in the studied DS sample as a whole and in those without
clinical fits (P>0.05). Psychosocial dysfunction scores were
significantly higher in patients with or without clinical fits when
compared with controls (p<0.01,P<0.001 respectively). Meanwhile,
patients without clinical fits had significantly higher psychosocial
dysfunction scores than those with clinical fits (p<0.05). IQ of enrolled
patients was negatively correlated with the psychosocial dysfunction score
but the correlation was statistically insignificant. Conclusion: the
results of the current study revealed a significant association between the
EEG changes in the form of focal discharge and lower IQ s in Down syndrome
children while they showed the lack of significant association between the
presence or the type of EEG changes and the degree of mental retardation,
the psychosocial dysfunction score, or the coexisted behavior and or psychiatric
disorders.