DETECTION of IgG ANTIBODIES to Cag A AMONG HEALTHY
CHILDREN IN JAKARTA
Kumala
W
Medical
faculty, University of Trisakti, Jakarta, Indonesia
Objective:
Helicobacter pylori infection
depends on the age, geographic location and sosio-economic condition.
Several strains of Helicobacter
pylori produce Cytotoxin Associated GenA (CagA) and it has been
determined as risk factor in the malignancy of stomach. This study is meant
to detect Ig G, Ig M antibodies to Helicobacter
pylori and IgG antibodies to CagA among healthy children in Jakarta.
Methods:
Sera samples were collected from 16 healthy infants, 45 healthy 1 - <5
years of age children and 90 healthy 5-15 years old children. The anti Helicobacter pylori Ig M, Ig G and
CagA were tested by ELISA.
Results:
No serum sample was positive by Ig M and Ig G from infants and children 1 -
< 5 years of age. Nine (10%) of 90 children from 5 - 15 years of age
were positive by IgM but negative by IgG. Three (3%) of 90 sera were
seropositiv by IgG antibodies to Helicobacter
pylori and positive by anti-CagA IgG antibodies.
Conclusions:
This study proves that acute infection of Helicobcter pylori, in which the IgM is positive, and
antibodies IgG to CagA occur at an early age.